Endocrine Abstracts

Pancreatic NETs (PanNETs) are characterized by recurrent molecular alterations, including genetic inactivation of MEN1, ATRX/DAXX, and activation of the PI3K/mTOR pathway. The International Cancer Genome Consortium effort on PanNETs provide a first snapshot of how heterogeneous is the combination of genetic alterations that drive this tumour type, yet converging into four pathways whose alteration has been enriched by newly discovered mechanisms. Whole-genome sequencing of 102...